Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin - Taddei - 2006 - International Journal of Cancer - Wiley Online Library
Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells - ScienceDirect
Activity of Aplidin on MM cell lines. A, dose-response matrix of human... | Download Scientific Diagram
Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity | Leukemia
Plitidepsin: design, development, and potential place in therapy | DDDT
Aplidin, plitidepsin, as PM90001 | PharmaMar
Aplidin, plitidepsin, as PM90001 | PharmaMar
Role of Cu 2+ in Aplidin s -induced apoptosis in MDA-MB-231 cells | Download Table
Of 72 antivirals tested in the laboratory, plitidepsin proves to be the most effective in preventing SARS-CoV-2 replication | IrsiCaixa
JPM | Free Full-Text | Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19 | HTML
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG) | Leukemia
Aplidin in patients with advanced dedifferentiated liposarcomas: a French Sarcoma Group Single-Arm Phase II study - Annals of Oncology
Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ | Oncogene
Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin - Taddei - 2006 - International Journal of Cancer - Wiley Online Library
Repurposing anticancer drugs for the management of COVID-19 - ScienceDirect
Frontiers | Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics | Immunology
AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK* - Journal of Biological Chemistry
Effect of Aplidin on MM cells stimulated with proliferative cytokines... | Download Scientific Diagram
PharmaMar discovers new data on the mechanism | EurekAlert!
Marine Drugs | Free Full-Text | Antitumor Peptides from Marine Organisms | HTML
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation | Cell Death & Differentiation
Plitidepsin: design, development, and potential place in therapy | DDDT
Phamamar achieve to extend the comercialization of its marine derived anti cancer drugs over eleven latinamerican countries.
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. - Abstract - Europe PMC
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Frontiers | Exploring the Diversity of the Marine Environment for New Anti-cancer Compounds | Marine Science
Oncology clinical pipeline marine inspired drugs | PharmaMar
